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Mechanical stress affects our chromatin

 
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Bernie



Joined: 23 Sep 2006
Posts: 1021
Location: Vancouver

PostPosted: Mon Sep 12, 2016 12:45 am    Post subject: Mechanical stress affects our chromatin Reply with quote

Mechanical force triggers gene expression by stretching chromatin
    "How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, a new study has demonstrated that external mechanical force can directly regulate gene expression. The study also identified the pathway that conveys the force from the outside of the cell into the nucleus."

    "Our findings suggest that local stresses applied to integrins propagate from the tensed actin cytoskeleton to the LINC complex and then through laminachromatin interactions to directly stretch chromatin and upregulate transcription."

When we stress our body in our yoga practice, we obviously stress our tissues. Our tissues are made up of cell, so we also stress the cells. This study shows how that stress on the cells can affect gene expression: turning on or off certain genes depending upon the direction and intensity of the stress. Unfortunately the study does not vary the nature of the stress nor discuss the effects of duration. That would be very interesting.
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